Transition-Metal-Catalyzed C–H Functionalization for the Synthesis of Substituted Pyridines Transition-Metal-Catalyzed C–H Functionalization
نویسنده
چکیده
SYNTHESIS 2011, No. 20, pp 3209–3219xx.xx.2011 Advanced online publication: 07.09.2011 DOI: 10.1055/s-0030-1260212; Art ID: E69311SS © Georg Thieme Verlag Stuttgart · New York Abstract: The direct functionalization of pyridine and related azine derivatives through carbon–carbon bond-forming reactions is reviewed. Various transformations that use a variety of transitionmetal catalysts are covered, including alkylation, alkenylation, arylation, and acylation. In addition to the conventionally observed C2selectivity for these transformations, recent developments involve selective introduction of newly formed carbon–carbon bonds to the C3and C4-positions of pyridine and azine nuclei. The reaction scope and a proposed mechanism for each transformation are briefly summarized.
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